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KMID : 0356920090570060737
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Korean Journal of Anesthesiology
2009 Volume.57 No. 6 p.737 ~ p.741
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Effect of remifentanil on QT dispersion
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Lee Won-Jin
Kim Young-Whan
Cho Kwang-Rae
Lee Sang-Eun
Lee Jeong-Han
Lim Se-Hun
Lee Kun-Moo
Cheong Soon-Ho
Choe Young-Kyun
Kim Young-Jae
Shin Chee-Mahn
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Abstract
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Background: QT dispersion (QTd) is an indirect measure of the heterogeneity of ventricular repolarization and can be used as a risk factor for complex ventricular arrhythmias. We measured the effect of remifentanil on QTd and heart-rate corrected QT dispersion (QTcd).
Methods: Sixty ASA class I and II patients, who were between 20 and 60 years old, and who were scheduled for general anesthesia, were studied. After the patient entered the operating room, a 12 lead EKG recording was taken and intravenous infusion of remifentanil was started. The infusion rate was 0.1 μg/kg/min in group 1 and 0.2 μg/kg/min in group 2. Another EKG recording was taken 10 minutes after infusion had started.
Results: In both groups, QTd following remifentanil infusion was not significantly different than control values (76.6 ± 23.3 ms vs 81.8 ± 34.9 ms, P = 0.459 in group 1; 70.7 ms ± 29.7 ms vs 73.7 ms ± 37.1 ms, P = 0.734 in group 2). Neither was QTcd: (83.2 ms ± 25.2 ms vs 89.6 ms ± 36.2 ms, P = 0.371 in group 1; 81.0 ms ± 35.2 ms vs 83.4 ms ± 40.9 ms, P = 0.829 in group 2).
Conclusions: Remifentanil infusion at a rate less than 0.2 μg/kg/min does not change QTd or QTcd.
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KEYWORD
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Arrhythmia, Heart conduction system, Remifentanil
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